Section 02

Full Neurochemical Pathway

The complete chain from threat detection to cortical shutdown. Click any node for compound information and receptor binding details.

Excitatory / Activation
Inhibitory
Stress Hormones
Feedback Loop

Chemical Compound Index

CompoundRoleReceptor/TargetLink
GlutamatePrimary excitatory NTNMDA, AMPA, kainate, mGluRPubChem 611
GABAPrimary inhibitory NTGABA-A, GABA-BPubChem 119
CortisolStress hormoneGlucocorticoid receptor (GR)PubChem 5754
CRHHPA axis initiatorCRH-R1, CRH-R2UniProt P06850
ACTHPituitary → adrenal signalMC2RUniProt P01189
NorepinephrineArousal / locus coeruleusα1, α2, β adrenergicPubChem 439260
EthanolGABAergic agonist / NMDA antagonistGABA-A (allosteric), NMDA (antagonist)PubChem 702
ClonazepamBenzodiazepine / GABA-A PAMGABA-A (α1,α2,α3,α5)PubChem 2802
RiluzoleGlutamate release inhibitorPresynaptic Na⁺ channels, EAAT2PubChem 5070
MemantineNMDA antagonist (voltage-dep.)NMDA receptor (channel blocker)PubChem 4054
LamotrigineGlutamate release inhibitorVoltage-gated Na⁺ channelsPubChem 3878
NACGlutamate modulatorCystine-glutamate antiporter (xCT)PubChem 12035
L-TheanineGlutamate analog / modulatorGlutamate receptors (partial)PubChem 228398
MagnesiumNMDA voltage-gate blockerNMDA receptor (Mg²⁺ block)PubChem 5462224
TaurineInhibitory neuromodulatorGABA-A, glycine receptorsPubChem 1123
← 01: Phenotype 03: Glutamate Storm →